JAK2 Inhibitor V ( NSC 42834; Janus-Associated Kinase Inhibitor V )

Catalog No. M18188 CAS No. 195371-52-9

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Product Name

JAK2 Inhibitor V
Note

Research use only, not for human use.
Brief Description

NSC 42834(JAK2 Inhibitor V, Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.
Description

NSC 42834, also known as JAK2 Inhibitor V, is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 μM.
Synonyms

NSC 42834; Janus-Associated Kinase Inhibitor V
Pathway

Others
Target

Other Targets
Recptor

JAK2; JAK2 (V617F)
Research Area

Cancer
Indication

——

CAS Number

195371-52-9
Formula Weight

344.45
Molecular Formula

C23H24N2O
Purity

98%
Solubility

DMSO : ≥ 43 mg/mL; 124.84 mM
SMILES

O=C(C(CCc1ccccn1)(CCc1ccccn1)C)c1ccccc1
Chemical Name

2-methyl-1-phenyl-4-(pyridin-2-yl)-2-(2-(pyridin-2-yl)ethyl)butan-1-one

1. Jacqueline Sayyah, et al. Mol Y Ther 2008;7(8):2308-18.

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